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@ARTICLE{Valk:907808,
      author       = {Valk, Sofie L. and Xu, Ting and Paquola, Casey and Park,
                      Bo-yong and Bethlehem, Richard A. I. and Vos de Wael,
                      Reinder and Royer, Jessica and Masouleh, Shahrzad Kharabian
                      and Bayrak, Şeyma and Kochunov, Peter and Yeo, B. T. Thomas
                      and Margulies, Daniel and Smallwood, Jonathan and Eickhoff,
                      Simon B. and Bernhardt, Boris C.},
      title        = {{G}enetic and phylogenetic uncoupling of structure and
                      function in human transmodal cortex},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2022-02227},
      pages        = {2341},
      year         = {2022},
      abstract     = {Brain structure scaffolds intrinsic function, supporting
                      cognition and ultimately behavioral flexibility. However, it
                      remains unclear how a static, genetically controlled
                      architecture supports flexible cognition and behavior. Here,
                      we synthesize genetic, phylogenetic and cognitive analyses
                      to understand how the macroscale organization of
                      structure-function coupling across the cortex can inform its
                      role in cognition. In humans, structure-function coupling
                      was highest in regions of unimodal cortex and lowest in
                      transmodal cortex, a pattern that was mirrored by a reduced
                      alignment with heritable connectivity profiles.
                      Structure-function uncoupling in macaques had a similar
                      spatial distribution, but we observed an increased coupling
                      between structure and function in association cortices
                      relative to humans. Meta-analysis suggested regions with the
                      least genetic control (low heritable correspondence and
                      different across primates) are linked to social-cognition
                      and autobiographical memory. Our findings suggest that
                      genetic and evolutionary uncoupling of structure and
                      function in different transmodal systems may support the
                      emergence of complex forms of cognition.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA2 - Human Brain Project Specific Grant
                      Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35534454},
      UT           = {WOS:000792848500017},
      doi          = {10.1038/s41467-022-29886-1},
      url          = {https://juser.fz-juelich.de/record/907808},
}