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| Hauptseite > Publikationsdatenbank > Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex > print |
| Hauptseite > Publikationsdatenbank > Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex > print |
| 001 | 907808 | ||
| 005 | 20230713203925.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-022-29886-1 |2 doi |
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| 100 | 1 | _ | |a Valk, Sofie L. |0 P:(DE-Juel1)173843 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
| 260 | _ | _ | |a [London] |c 2022 |b Nature Publishing Group UK |
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| 520 | _ | _ | |a Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition. |
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| 773 | _ | _ | |a 10.1038/s41467-022-29886-1 |g Vol. 13, no. 1, p. 2341 |0 PERI:(DE-600)2553671-0 |n 1 |p 2341 |t Nature Communications |v 13 |y 2022 |x 2041-1723 |
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