TY - JOUR
AU - Kamalian, Aida
AU - Khodadadifar, Tina
AU - Saberi, Amin
AU - Masoudi, Maryam
AU - Camilleri, Julia
AU - Eickhoff, Claudia R.
AU - Zarei, Mojtaba
AU - Pasquini, Lorenzo
AU - Laird, Angela R.
AU - Fox, Peter T.
AU - Eickhoff, Simon B.
AU - Tahmasian, Masoud
TI - Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta‐analysis of 73 studies
JO - Alzheimer's & dementia / Diagnosis, assessment & disease monitoring
VL - 14
IS - 1
SN - 2352-8729
CY - Hoboken, NJ
PB - Wiley
M1 - FZJ-2022-02281
SP - e12318
PY - 2022
AB - IntroductionNumerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings.MethodsWe used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best-practice neuroimaging meta-analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and controls from 73 studies were extracted and tested for convergence using activation likelihood estimation.ResultsWe identified convergent abnormalities in the anterior cingulate cortices, anterior insula, amygdala, paracingulate, striatum, and hippocampus. Task-based and resting-state functional connectivity pointed to the networks that are connected to the obtained consistent regions. Functional decoding analyses suggested associated dysfunction of emotional processing, interoception, reward processing, higher-order cognitive functions, and olfactory and gustatory perceptions in bvFTD.DiscussionOur findings highlighted the key role of the salience network and subcortical regions in the pathophysiology of bvFTD.
LB - PUB:(DE-HGF)16
C6 - 35664889
UR - <Go to ISI:>//WOS:000801225700001
DO - DOI:10.1002/dad2.12318
UR - https://juser.fz-juelich.de/record/907914
ER -