Journal Article

FZJ-2022-02281

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta‐analysis of 73 studies

Kamalian, A. ; Khodadadifar, T. ; Saberi, A.FZJ* ; Masoudi, M. ; Camilleri, J.FZJ* ; Eickhoff, C. R.FZJ* ; Zarei, M. ; Pasquini, L. ; Laird, A. R. ; Fox, P. T. ; Eickhoff, S. B.FZJ* ; Tahmasian, M. (Corresponding author)FZJ*

2022
Wiley Hoboken, NJ

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Please use a persistent id in citations: http://hdl.handle.net/2128/31243  doi:10.1002/dad2.12318

Abstract: IntroductionNumerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings.MethodsWe used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best-practice neuroimaging meta-analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and controls from 73 studies were extracted and tested for convergence using activation likelihood estimation.ResultsWe identified convergent abnormalities in the anterior cingulate cortices, anterior insula, amygdala, paracingulate, striatum, and hippocampus. Task-based and resting-state functional connectivity pointed to the networks that are connected to the obtained consistent regions. Functional decoding analyses suggested associated dysfunction of emotional processing, interoception, reward processing, higher-order cognitive functions, and olfactory and gustatory perceptions in bvFTD.DiscussionOur findings highlighted the key role of the salience network and subcortical regions in the pathophysiology of bvFTD.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; SCOPUS ; Web of Science Core Collection

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