Gast ::
| Hauptseite > Publikationsdatenbank > Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin. > print |
| Hauptseite > Publikationsdatenbank > Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin. > print |
| 001 | 909069 | ||
| 005 | 20230123110638.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-022-30042-y |2 doi |
| 024 | 7 | _ | |a pmid:35501361 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC9061850 |2 pmc |
| 024 | 7 | _ | |a 2128/31660 |2 Handle |
| 024 | 7 | _ | |a WOS:000789924700014 |2 WOS |
| 037 | _ | _ | |a FZJ-2022-02987 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Törner, Ricarda |0 0000-0002-0775-2075 |b 0 |
| 245 | _ | _ | |a Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin. |
| 260 | _ | _ | |a [London] |c 2022 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1661167318_2171 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Chaperones, as modulators of protein conformational states, are key cellular actors to prevent the accumulation of fibrillar aggregates. Here, we integrated kinetic investigations with structural studies to elucidate how the ubiquitous co-chaperonin prefoldin inhibits diabetes associated islet amyloid polypeptide (IAPP) fibril formation. We demonstrated that both human and archaeal prefoldin interfere similarly with the IAPP fibril elongation and secondary nucleation pathways. Using archaeal prefoldin model, we combined nuclear magnetic resonance spectroscopy with electron microscopy to establish that the inhibition of fibril formation is mediated by the binding of prefoldin's coiled-coil helices to the flexible IAPP N-terminal segment accessible on the fibril surface and fibril ends. Atomic force microscopy demonstrates that binding of prefoldin to IAPP leads to the formation of lower amounts of aggregates, composed of shorter fibrils, clustered together. Linking structural models with observed fibrillation inhibition processes opens perspectives for understanding the interference between natural chaperones and formation of disease-associated amyloids. |
| 536 | _ | _ | |a 5244 - Information Processing in Neuronal Networks (POF4-524) |0 G:(DE-HGF)POF4-5244 |c POF4-524 |f POF IV |x 0 |
| 536 | _ | _ | |a BETACONTROL - Control of amyloid formation via beta-hairpin molecular recognition features (726368) |0 G:(EU-Grant)726368 |c 726368 |f ERC-2016-COG |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: juser.fz-juelich.de |
| 650 | _ | 7 | |a Amyloid |2 NLM Chemicals |
| 650 | _ | 7 | |a Islet Amyloid Polypeptide |2 NLM Chemicals |
| 650 | _ | 7 | |a Molecular Chaperones |2 NLM Chemicals |
| 650 | _ | 7 | |a prefoldin |2 NLM Chemicals |
| 650 | _ | 7 | |a Chaperonins |0 EC 3.6.1.- |2 NLM Chemicals |
| 650 | _ | 2 | |a Amyloid: metabolism |2 MeSH |
| 650 | _ | 2 | |a Chaperonins |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Islet Amyloid Polypeptide |2 MeSH |
| 650 | _ | 2 | |a Molecular Chaperones: metabolism |2 MeSH |
| 700 | 1 | _ | |a Kupreichyk, Tatsiana |0 P:(DE-Juel1)176456 |b 1 |
| 700 | 1 | _ | |a Gremer, Lothar |0 P:(DE-Juel1)145165 |b 2 |
| 700 | 1 | _ | |a Debled, Elisa Colas |0 0000-0002-8279-3053 |b 3 |
| 700 | 1 | _ | |a Fenel, Daphna |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Schemmert, Sarah |0 P:(DE-Juel1)165908 |b 5 |u fzj |
| 700 | 1 | _ | |a Gans, Pierre |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 7 |
| 700 | 1 | _ | |a Schoehn, Guy |0 0000-0002-1459-3201 |b 8 |
| 700 | 1 | _ | |a Hoyer, Wolfgang |0 P:(DE-Juel1)166306 |b 9 |e Corresponding author |
| 700 | 1 | _ | |a Boisbouvier, Jerome |0 0000-0003-3278-3639 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s41467-022-30042-y |g Vol. 13, no. 1, p. 2363 |0 PERI:(DE-600)2553671-0 |n 1 |p 2363 |t Nature Communications |v 13 |y 2022 |x 2041-1723 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/909069/files/T%C3%B6rner%202022%20Nat%20Commun%2C%20Prefoldin-IAPP%20interaction.pdf |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:909069 |p openaire |p open_access |p driver |p VDB |p ec_fundedresources |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)176456 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)145165 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 5 |6 P:(DE-Juel1)165908 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)132029 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 9 |6 P:(DE-Juel1)166306 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-524 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Molecular and Cellular Information Processing |9 G:(DE-HGF)POF4-5244 |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2021-02-02 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-02-02 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2021-02-02 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-02-02 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-02-02 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT COMMUN : 2021 |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Peer review |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2022-11-11 |
| 915 | _ | _ | |a IF >= 15 |0 StatID:(DE-HGF)9915 |2 StatID |b NAT COMMUN : 2021 |d 2022-11-11 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)IBI-7-20200312 |k IBI-7 |l Strukturbiochemie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|