%0 Journal Article
%A Doppler, Christopher E. J.
%A Smit, Julia
%A Hommelsen, Maximilian
%A Seger, Aline
%A Okkels, Niels
%A Horsager, Jacob
%A Kinnerup, Martin
%A Hansen, Allan K.
%A Fedorova, Tatyana D.
%A Knudsen, Karoline
%A Otto, Marit
%A Nahimi, Adjmal
%A Fink, Gereon R.
%A Borghammer, Per
%A Sommerauer, Michael
%T Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease
%J Journal of Parkinson's Disease
%V 12
%N 8
%@ 1877-7171
%C Amsterdam
%I IOS Press
%M FZJ-2022-03544
%P 2555-256
%D 2022
%X AbstractBackground:Although sleep disturbances are highly prevalent in patients with Parkinson’s disease, sleep macroarchitecture metrics show only minor changes.Objective:To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson’s disease.Methods:We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.Results:Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.Conclusion:Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson’s disease than changes in sleep macroarchitecture.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36189604
%U <Go to ISI:>//WOS:000903412100023
%R 10.3233/JPD-223442
%U https://juser.fz-juelich.de/record/909954