guest ::
| Home > Publications database > Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease |
| Home > Publications database > Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease |
| Journal Article | FZJ-2022-03544 |
; ; ; ; ; ; ; ; ; ; ; ; ; ;
2022
IOS Press
Amsterdam
This record in other databases: 
Please use a persistent id in citations: doi:10.3233/JPD-223442
Abstract: AbstractBackground:Although sleep disturbances are highly prevalent in patients with Parkinson’s disease, sleep macroarchitecture metrics show only minor changes.Objective:To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson’s disease.Methods:We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.Results:Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.Conclusion:Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson’s disease than changes in sleep macroarchitecture.
; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Essential Science Indicators ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
DOCX