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000909954 1001_ $$0P:(DE-Juel1)161350$$aDoppler, Christopher E. J.$$b0$$ufzj
000909954 245__ $$aDisruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease
000909954 260__ $$aAmsterdam$$bIOS Press$$c2022
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000909954 520__ $$aAbstractBackground:Although sleep disturbances are highly prevalent in patients with Parkinson’s disease, sleep macroarchitecture metrics show only minor changes.Objective:To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson’s disease.Methods:We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.Results:Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.Conclusion:Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson’s disease than changes in sleep macroarchitecture.
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000909954 7001_ $$0P:(DE-HGF)0$$aSmit, Julia$$b1
000909954 7001_ $$0P:(DE-Juel1)173028$$aHommelsen, Maximilian$$b2
000909954 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline$$b3$$ufzj
000909954 7001_ $$0P:(DE-HGF)0$$aOkkels, Niels$$b4
000909954 7001_ $$0P:(DE-HGF)0$$aHorsager, Jacob$$b5
000909954 7001_ $$0P:(DE-HGF)0$$aKinnerup, Martin$$b6
000909954 7001_ $$0P:(DE-HGF)0$$aHansen, Allan K.$$b7
000909954 7001_ $$0P:(DE-HGF)0$$aFedorova, Tatyana D.$$b8
000909954 7001_ $$0P:(DE-HGF)0$$aKnudsen, Karoline$$b9
000909954 7001_ $$0P:(DE-HGF)0$$aOtto, Marit$$b10
000909954 7001_ $$0P:(DE-HGF)0$$aNahimi, Adjmal$$b11
000909954 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b12$$ufzj
000909954 7001_ $$0P:(DE-HGF)0$$aBorghammer, Per$$b13
000909954 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b14$$eCorresponding author$$ufzj
000909954 773__ $$0PERI:(DE-600)2599550-9$$a10.3233/JPD-223442$$gp. 1 - 6$$n8$$p2555-256$$tJournal of Parkinson's Disease$$v12$$x1877-7171$$y2022
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