TY  - JOUR
AU  - Doppler, Christopher E. J.
AU  - Smit, Julia
AU  - Hommelsen, Maximilian
AU  - Seger, Aline
AU  - Okkels, Niels
AU  - Horsager, Jacob
AU  - Kinnerup, Martin
AU  - Hansen, Allan K.
AU  - Fedorova, Tatyana D.
AU  - Knudsen, Karoline
AU  - Otto, Marit
AU  - Nahimi, Adjmal
AU  - Fink, Gereon R.
AU  - Borghammer, Per
AU  - Sommerauer, Michael
TI  - Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease
JO  - Journal of Parkinson's Disease
VL  - 12
IS  - 8
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2022-03544
SP  - 2555-256
PY  - 2022
AB  - AbstractBackground:Although sleep disturbances are highly prevalent in patients with Parkinson’s disease, sleep macroarchitecture metrics show only minor changes.Objective:To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson’s disease.Methods:We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.Results:Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.Conclusion:Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson’s disease than changes in sleep macroarchitecture.
LB  - PUB:(DE-HGF)16
C6  - 36189604
UR  - <Go to ISI:>//WOS:000903412100023
DO  - DOI:10.3233/JPD-223442
UR  - https://juser.fz-juelich.de/record/909954
ER  -