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@ARTICLE{Doppler:909954,
author = {Doppler, Christopher E. J. and Smit, Julia and Hommelsen,
Maximilian and Seger, Aline and Okkels, Niels and Horsager,
Jacob and Kinnerup, Martin and Hansen, Allan K. and
Fedorova, Tatyana D. and Knudsen, Karoline and Otto, Marit
and Nahimi, Adjmal and Fink, Gereon R. and Borghammer, Per
and Sommerauer, Michael},
title = {{D}isruption of {S}leep {M}icroarchitecture {I}s a
{S}ensitive and {E}arly {M}arker of {P}arkinson’s
{D}isease},
journal = {Journal of Parkinson's Disease},
volume = {12},
number = {8},
issn = {1877-7171},
address = {Amsterdam},
publisher = {IOS Press},
reportid = {FZJ-2022-03544},
pages = {2555-256},
year = {2022},
abstract = {AbstractBackground:Although sleep disturbances are highly
prevalent in patients with Parkinson’s disease, sleep
macroarchitecture metrics show only minor
changes.Objective:To assess alterations of the cyclic
alternating pattern (CAP) as a critical feature of sleep
microarchitecture in patients with prodromal, recent, and
established Parkinson’s disease.Methods:We evaluated
overnight polysomnography for classic sleep
macroarchitecture and CAP metrics in 68 patients at various
disease stages and compared results to 22 age- and
sex-matched controls.Results:Already at the prodromal stage,
patients showed a significantly reduced CAP rate as a
central characteristic of sleep microarchitecture. Temporal
characteristics of CAP showed a gradual change over disease
stages and correlated with motor performance. In contrast,
the sleep macroarchitecture metrics did not differ between
groups.Conclusion:Data suggest that alterations of sleep
microarchitecture are an early and more sensitive
characteristic of Parkinson’s disease than changes in
sleep macroarchitecture.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {36189604},
UT = {WOS:000903412100023},
doi = {10.3233/JPD-223442},
url = {https://juser.fz-juelich.de/record/909954},
}