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@ARTICLE{Doppler:909954,
      author       = {Doppler, Christopher E. J. and Smit, Julia and Hommelsen,
                      Maximilian and Seger, Aline and Okkels, Niels and Horsager,
                      Jacob and Kinnerup, Martin and Hansen, Allan K. and
                      Fedorova, Tatyana D. and Knudsen, Karoline and Otto, Marit
                      and Nahimi, Adjmal and Fink, Gereon R. and Borghammer, Per
                      and Sommerauer, Michael},
      title        = {{D}isruption of {S}leep {M}icroarchitecture {I}s a
                      {S}ensitive and {E}arly {M}arker of {P}arkinson’s
                      {D}isease},
      journal      = {Journal of Parkinson's Disease},
      volume       = {12},
      number       = {8},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2022-03544},
      pages        = {2555-256},
      year         = {2022},
      abstract     = {AbstractBackground:Although sleep disturbances are highly
                      prevalent in patients with Parkinson’s disease, sleep
                      macroarchitecture metrics show only minor
                      changes.Objective:To assess alterations of the cyclic
                      alternating pattern (CAP) as a critical feature of sleep
                      microarchitecture in patients with prodromal, recent, and
                      established Parkinson’s disease.Methods:We evaluated
                      overnight polysomnography for classic sleep
                      macroarchitecture and CAP metrics in 68 patients at various
                      disease stages and compared results to 22 age- and
                      sex-matched controls.Results:Already at the prodromal stage,
                      patients showed a significantly reduced CAP rate as a
                      central characteristic of sleep microarchitecture. Temporal
                      characteristics of CAP showed a gradual change over disease
                      stages and correlated with motor performance. In contrast,
                      the sleep macroarchitecture metrics did not differ between
                      groups.Conclusion:Data suggest that alterations of sleep
                      microarchitecture are an early and more sensitive
                      characteristic of Parkinson’s disease than changes in
                      sleep macroarchitecture.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36189604},
      UT           = {WOS:000903412100023},
      doi          = {10.3233/JPD-223442},
      url          = {https://juser.fz-juelich.de/record/909954},
}