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| 001 | 909954 | ||
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| 024 | 7 | _ | |a 10.3233/JPD-223442 |2 doi |
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| 024 | 7 | _ | |a WOS:000903412100023 |2 WOS |
| 037 | _ | _ | |a FZJ-2022-03544 |
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| 100 | 1 | _ | |a Doppler, Christopher E. J. |0 P:(DE-Juel1)161350 |b 0 |u fzj |
| 245 | _ | _ | |a Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease |
| 260 | _ | _ | |a Amsterdam |c 2022 |b IOS Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a AbstractBackground:Although sleep disturbances are highly prevalent in patients with Parkinson’s disease, sleep macroarchitecture metrics show only minor changes.Objective:To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson’s disease.Methods:We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.Results:Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.Conclusion:Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson’s disease than changes in sleep macroarchitecture. |
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| 700 | 1 | _ | |a Okkels, Niels |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Horsager, Jacob |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Kinnerup, Martin |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Hansen, Allan K. |0 P:(DE-HGF)0 |b 7 |
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| 700 | 1 | _ | |a Sommerauer, Michael |0 P:(DE-Juel1)179044 |b 14 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.3233/JPD-223442 |g p. 1 - 6 |0 PERI:(DE-600)2599550-9 |n 8 |p 2555-256 |t Journal of Parkinson's Disease |v 12 |y 2022 |x 1877-7171 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/909954/files/Invoice_P20222388.pdf |
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| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/909954/files/jpd_2022_12-8_jpd-12-8-jpd223442_jpd-12-jpd223442.pdf |y Restricted |
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