000917508 001__ 917508
000917508 005__ 20230929112506.0
000917508 0247_ $$2doi$$a10.1002/cite.202200178
000917508 0247_ $$2ISSN$$a0009-286X
000917508 0247_ $$2ISSN$$a1522-2640
000917508 0247_ $$2Handle$$a2128/34204
000917508 0247_ $$2WOS$$aWOS:000914001400001
000917508 037__ $$aFZJ-2023-00721
000917508 082__ $$a660
000917508 1001_ $$0P:(DE-Juel1)174185$$aSehl, Torsten$$b0$$eCorresponding author
000917508 245__ $$aEnzymatic (2 R ,4 R )‐Pentanediol Synthesis – “Putting a Bottle on the Table”
000917508 260__ $$aWeinheim$$bWiley-VCH Verl.$$c2023
000917508 3367_ $$2DRIVER$$aarticle
000917508 3367_ $$2DataCite$$aOutput Types/Journal article
000917508 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1683530991_21000
000917508 3367_ $$2BibTeX$$aARTICLE
000917508 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000917508 3367_ $$00$$2EndNote$$aJournal Article
000917508 520__ $$a(2R,4R)-Pentanediol is an interesting precursor for the synthesis of chiral ligands. A ketoreductase (KRED) was employed for the asymmetric reduction of acetylacetone to this diol. Biocatalysis often suffers from low concentrations of hydrophobic substrates and low stability of the enzyme in unconventional media. Here, we present an engineered KRED variant applicable in a neat substrate system, including upscaling to the multi-liter scale and downstream processing (DSP). Our engineered KRED applied in a neat substrate system is a powerful technique for the synthesis of chiral diols yielding product concentrations of 208 g L−1.
000917508 536__ $$0G:(DE-HGF)POF4-2172$$a2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217)$$cPOF4-217$$fPOF IV$$x0
000917508 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000917508 7001_ $$0P:(DE-Juel1)188344$$aSeibt, Lisa$$b1$$ufzj
000917508 7001_ $$0P:(DE-Juel1)179370$$aKappauf, Katrin$$b2
000917508 7001_ $$0P:(DE-HGF)0$$aErgezinger, Pia$$b3
000917508 7001_ $$0P:(DE-Juel1)178052$$aSpöring, Jan-Dirk$$b4
000917508 7001_ $$0P:(DE-HGF)0$$aMielke, Kristina$$b5
000917508 7001_ $$aDoeker, Moritz$$b6
000917508 7001_ $$0P:(DE-HGF)0$$aVerma, Neha$$b7
000917508 7001_ $$0P:(DE-HGF)0$$aBocola, Marco$$b8
000917508 7001_ $$0P:(DE-HGF)0$$aDaußmann, Thomas$$b9
000917508 7001_ $$00000-0003-2589-7347$$aChen, Haibin$$b10
000917508 7001_ $$0P:(DE-HGF)0$$aShi, Shumin$$b11
000917508 7001_ $$0P:(DE-Juel1)194474$$aJupke, Andreas$$b12
000917508 7001_ $$0P:(DE-Juel1)144643$$aRother, Dörte$$b13$$eCorresponding author
000917508 773__ $$0PERI:(DE-600)2035041-7$$a10.1002/cite.202200178$$gp. cite.202200178$$n4$$p557-564$$tChemie - Ingenieur - Technik$$v95$$x0009-286X$$y2023
000917508 8564_ $$uhttps://juser.fz-juelich.de/record/917508/files/Invoice_5803476.pdf
000917508 8564_ $$uhttps://juser.fz-juelich.de/record/917508/files/Chemie%20Ingenieur%20Technik%20-%202023%20-%20Sehl%20-%20Enzymatic%202R%204R%20%E2%80%90Pentanediol%20Synthesis%20Putting%20a%20Bottle%20on%20the%20Table.pdf$$yOpenAccess
000917508 8767_ $$d2023-01-17$$eHybrid-OA$$jDEAL
000917508 8767_ $$85803476$$92023-04-12$$d2023-05-31$$eColour charges$$jZahlung erfolgt$$zRechnung wurde direkt übers Institut freigegeben
000917508 909CO $$ooai:juser.fz-juelich.de:917508$$pdnbdelivery$$popenCost$$pVDB$$pdriver$$pOpenAPC_DEAL$$pOpenAPC$$popen_access$$popenaire
000917508 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174185$$aForschungszentrum Jülich$$b0$$kFZJ
000917508 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188344$$aForschungszentrum Jülich$$b1$$kFZJ
000917508 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)178052$$aForschungszentrum Jülich$$b4$$kFZJ
000917508 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)194474$$aForschungszentrum Jülich$$b12$$kFZJ
000917508 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144643$$aForschungszentrum Jülich$$b13$$kFZJ
000917508 9131_ $$0G:(DE-HGF)POF4-217$$1G:(DE-HGF)POF4-210$$2G:(DE-HGF)POF4-200$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-2172$$aDE-HGF$$bForschungsbereich Erde und Umwelt$$lErde im Wandel – Unsere Zukunft nachhaltig gestalten$$vFür eine nachhaltige Bio-Ökonomie – von Ressourcen zu Produkten$$x0
000917508 9141_ $$y2023
000917508 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000917508 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000917508 915pc $$0PC:(DE-HGF)0002$$2APC$$aDFG OA Publikationskosten
000917508 915pc $$0PC:(DE-HGF)0120$$2APC$$aDEAL: Wiley 2019
000917508 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-08
000917508 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000917508 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2022-11-08$$wger
000917508 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-08
000917508 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000917508 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-26$$wger
000917508 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCHEM-ING-TECH : 2022$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)1160$$2StatID$$aDBCoverage$$bCurrent Contents - Engineering, Computing and Technology$$d2023-08-26
000917508 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-26
000917508 9201_ $$0I:(DE-Juel1)IBG-1-20101118$$kIBG-1$$lBiotechnologie$$x0
000917508 980__ $$ajournal
000917508 980__ $$aVDB
000917508 980__ $$aI:(DE-Juel1)IBG-1-20101118
000917508 980__ $$aAPC
000917508 980__ $$aUNRESTRICTED
000917508 9801_ $$aAPC
000917508 9801_ $$aFullTexts