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@ARTICLE{Sehl:917508,
      author       = {Sehl, Torsten and Seibt, Lisa and Kappauf, Katrin and
                      Ergezinger, Pia and Spöring, Jan-Dirk and Mielke, Kristina
                      and Doeker, Moritz and Verma, Neha and Bocola, Marco and
                      Daußmann, Thomas and Chen, Haibin and Shi, Shumin and
                      Jupke, Andreas and Rother, Dörte},
      title        = {{E}nzymatic (2 {R} ,4 {R} )‐{P}entanediol {S}ynthesis –
                      “{P}utting a {B}ottle on the {T}able”},
      journal      = {Chemie - Ingenieur - Technik},
      volume       = {95},
      number       = {4},
      issn         = {0009-286X},
      address      = {Weinheim},
      publisher    = {Wiley-VCH Verl.},
      reportid     = {FZJ-2023-00721},
      pages        = {557-564},
      year         = {2023},
      abstract     = {(2R,4R)-Pentanediol is an interesting precursor for the
                      synthesis of chiral ligands. A ketoreductase (KRED) was
                      employed for the asymmetric reduction of acetylacetone to
                      this diol. Biocatalysis often suffers from low
                      concentrations of hydrophobic substrates and low stability
                      of the enzyme in unconventional media. Here, we present an
                      engineered KRED variant applicable in a neat substrate
                      system, including upscaling to the multi-liter scale and
                      downstream processing (DSP). Our engineered KRED applied in
                      a neat substrate system is a powerful technique for the
                      synthesis of chiral diols yielding product concentrations of
                      208 g L−1.},
      cin          = {IBG-1},
      ddc          = {660},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000914001400001},
      doi          = {10.1002/cite.202200178},
      url          = {https://juser.fz-juelich.de/record/917508},
}