TY  - JOUR
AU  - Midya, Jiarul
AU  - Auth, Thorsten
AU  - Gompper, Gerhard
TI  - Membrane-Mediated Interactions Between Nonspherical Elastic Particles
JO  - ACS nano
VL  - 17
IS  - 3
SN  - 1936-0851
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2023-01081
SP  - 1935–1945
PY  - 2023
AB  - The transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with their environment. Large particles often get wrapped by membranes, a process which has been intensively investigated in the case of hard particles. However, many particles in vivo and in vitro are deformable, e.g., vesicles, filamentous viruses, macromolecular condensates, polymer-grafted nanoparticles, and microgels. Vesicles may serve as a generic model system for deformable particles. Here, we study nonspherical vesicles with various sizes, shapes, and elastic properties at initially planar lipid-bilayer membranes. Using the Helfrich Hamiltonian, triangulated membranes, and energy minimization, we predict the interplay of vesicle shapes and wrapping states. Increasing particle softness enhances the stability of shallow-wrapped and deep-wrapped states over nonwrapped and complete-wrapped states. The free membrane mediates an interaction between partial-wrapped vesicles. For the pair interaction between deep-wrapped vesicles, we predict repulsion. For shallow-wrapped vesicles, we predict attraction for tip-to-tip orientation and repulsion for side-by-side orientation. Our predictions may guide the design and fabrication of deformable particles for efficient use in medical applications, such as targeted drug delivery.
LB  - PUB:(DE-HGF)16
C6  - 36669092
UR  - <Go to ISI:>//WOS:000921840800001
DO  - DOI:10.1021/acsnano.2c05801
UR  - https://juser.fz-juelich.de/record/972119
ER  -