%0 Journal Article
%A Bartnik, D.
%A Funke, S. A.
%A Andrei-Selmer, L.C.
%A Bacher, M.
%A Dodel, R.
%A Willbold, D.
%T Differently Selected D-Enantiomeric Peptides Act on Different A beta Species
%J Rejuvenation research
%V 13
%@ 1549-1684
%C Larchmont, NY
%I Liebert
%M PreJuSER-9877
%D 2010
%Z Record converted from VDB: 12.11.2012
%X Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was selected against aggregated Abeta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight Abeta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.
%K Alzheimer Disease: diagnosis
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: pathology
%K Amyloid: analysis
%K Amyloid: chemistry
%K Amyloid beta-Peptides: chemistry
%K Amyloid beta-Peptides: drug effects
%K Amyloid beta-Peptides: metabolism
%K Humans
%K Oligopeptides: chemistry
%K Oligopeptides: metabolism
%K Oligopeptides: pharmacology
%K Peptide Fragments: chemistry
%K Peptide Fragments: isolation & purification
%K Peptide Fragments: metabolism
%K Peptide Fragments: pharmacology
%K Plaque, Amyloid: chemistry
%K Plaque, Amyloid: drug effects
%K Plaque, Amyloid: metabolism
%K Protein Binding
%K Protein Isoforms: analysis
%K Protein Isoforms: chemistry
%K Protein Multimerization: drug effects
%K Substrate Specificity
%K Surface Plasmon Resonance
%K Amyloid (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K D3 peptide (NLM Chemicals)
%K Oligopeptides (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K Protein Isoforms (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:19954333
%U <Go to ISI:>//WOS:000277602200017
%R 10.1089/rej.2009.0924
%U https://juser.fz-juelich.de/record/9877