Journal Article

PreJuSER-9877

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Differently Selected D-Enantiomeric Peptides Act on Different A beta Species

Bartnik, D.FZJ* ; Funke, S. A.FZJ* ; Andrei-Selmer, L. C. ; Bacher, M. ; Dodel, R. ; Willbold, D.FZJ*

2010
Liebert Larchmont, NY

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Please use a persistent id in citations: doi:10.1089/rej.2009.0924

Abstract: Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was selected against aggregated Abeta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight Abeta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.

Keyword(s): Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Amyloid: analysis (MeSH) ; Amyloid: chemistry (MeSH) ; Amyloid beta-Peptides: chemistry (MeSH) ; Amyloid beta-Peptides: drug effects (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Humans (MeSH) ; Oligopeptides: chemistry (MeSH) ; Oligopeptides: metabolism (MeSH) ; Oligopeptides: pharmacology (MeSH) ; Peptide Fragments: chemistry (MeSH) ; Peptide Fragments: isolation & purification (MeSH) ; Peptide Fragments: metabolism (MeSH) ; Peptide Fragments: pharmacology (MeSH) ; Plaque, Amyloid: chemistry (MeSH) ; Plaque, Amyloid: drug effects (MeSH) ; Plaque, Amyloid: metabolism (MeSH) ; Protein Binding (MeSH) ; Protein Isoforms: analysis (MeSH) ; Protein Isoforms: chemistry (MeSH) ; Protein Multimerization: drug effects (MeSH) ; Substrate Specificity (MeSH) ; Surface Plasmon Resonance (MeSH) ; Amyloid ; Amyloid beta-Peptides ; D3 peptide ; Oligopeptides ; Peptide Fragments ; Protein Isoforms ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Strukturbiochemie (ISB-3)
2. Jülich Aachen Research Alliance - High-Performance Computing (JARA-HPC)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)
2. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2010

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