TY  - JOUR
AU  - Bartnik, D.
AU  - Funke, S. A.
AU  - Andrei-Selmer, L.C.
AU  - Bacher, M.
AU  - Dodel, R.
AU  - Willbold, D.
TI  - Differently Selected D-Enantiomeric Peptides Act on Different A beta Species
JO  - Rejuvenation research
VL  - 13
SN  - 1549-1684
CY  - Larchmont, NY
PB  - Liebert
M1  - PreJuSER-9877
PY  - 2010
N1  - Record converted from VDB: 12.11.2012
AB  - Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was selected against aggregated Abeta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight Abeta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Amyloid: analysis
KW  - Amyloid: chemistry
KW  - Amyloid beta-Peptides: chemistry
KW  - Amyloid beta-Peptides: drug effects
KW  - Amyloid beta-Peptides: metabolism
KW  - Humans
KW  - Oligopeptides: chemistry
KW  - Oligopeptides: metabolism
KW  - Oligopeptides: pharmacology
KW  - Peptide Fragments: chemistry
KW  - Peptide Fragments: isolation & purification
KW  - Peptide Fragments: metabolism
KW  - Peptide Fragments: pharmacology
KW  - Plaque, Amyloid: chemistry
KW  - Plaque, Amyloid: drug effects
KW  - Plaque, Amyloid: metabolism
KW  - Protein Binding
KW  - Protein Isoforms: analysis
KW  - Protein Isoforms: chemistry
KW  - Protein Multimerization: drug effects
KW  - Substrate Specificity
KW  - Surface Plasmon Resonance
KW  - Amyloid (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - D3 peptide (NLM Chemicals)
KW  - Oligopeptides (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - Protein Isoforms (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19954333
UR  - <Go to ISI:>//WOS:000277602200017
DO  - DOI:10.1089/rej.2009.0924
UR  - https://juser.fz-juelich.de/record/9877
ER  -