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@ARTICLE{Bartnik:9877,
author = {Bartnik, D. and Funke, S. A. and Andrei-Selmer, L.C. and
Bacher, M. and Dodel, R. and Willbold, D.},
title = {{D}ifferently {S}elected {D}-{E}nantiomeric {P}eptides
{A}ct on {D}ifferent {A} beta {S}pecies},
journal = {Rejuvenation research},
volume = {13},
issn = {1549-1684},
address = {Larchmont, NY},
publisher = {Liebert},
reportid = {PreJuSER-9877},
year = {2010},
note = {Record converted from VDB: 12.11.2012},
abstract = {Aging is the most significant risk factor for Alzheimer
disease (AD). The pathological hallmark of AD is the
accumulation of aggregated amyloid-beta (Abeta) forms and
insoluble plaques, mainly composed of Abeta, in the brain of
the patient. Recently, we reported on the selection of
D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was
selected against aggregated Abeta species to address
diagnosis by in vivo imaging of amyloid plaques, whereas D3
was selected using low-molecular-weight Abeta species,
therefore addressing therapeutical studies. Here, we use a
surface plasmon resonance method to confirm that both
peptides show the desired binding specificities.},
keywords = {Alzheimer Disease: diagnosis / Alzheimer Disease:
metabolism / Alzheimer Disease: pathology / Amyloid:
analysis / Amyloid: chemistry / Amyloid beta-Peptides:
chemistry / Amyloid beta-Peptides: drug effects / Amyloid
beta-Peptides: metabolism / Humans / Oligopeptides:
chemistry / Oligopeptides: metabolism / Oligopeptides:
pharmacology / Peptide Fragments: chemistry / Peptide
Fragments: isolation $\&$ purification / Peptide Fragments:
metabolism / Peptide Fragments: pharmacology / Plaque,
Amyloid: chemistry / Plaque, Amyloid: drug effects / Plaque,
Amyloid: metabolism / Protein Binding / Protein Isoforms:
analysis / Protein Isoforms: chemistry / Protein
Multimerization: drug effects / Substrate Specificity /
Surface Plasmon Resonance / Amyloid (NLM Chemicals) /
Amyloid beta-Peptides (NLM Chemicals) / D3 peptide (NLM
Chemicals) / Oligopeptides (NLM Chemicals) / Peptide
Fragments (NLM Chemicals) / Protein Isoforms (NLM Chemicals)
/ J (WoSType)},
cin = {ISB-3 / JARA-HPC},
ddc = {610},
cid = {I:(DE-Juel1)VDB942 / $I:(DE-82)080012_20140620$},
pnm = {Funktion und Dysfunktion des Nervensystems / BioSoft:
Makromolekulare Systeme und biologische
Informationsverarbeitung},
pid = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505},
shelfmark = {Geriatrics $\&$ Gerontology},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:19954333},
UT = {WOS:000277602200017},
doi = {10.1089/rej.2009.0924},
url = {https://juser.fz-juelich.de/record/9877},
}