Journal Article

Evaluating the cognitive capacities of large language models (LLMs) requires overcoming not only anthropomorphic but also anthropocentric biases. This article identifies two types of anthropocentric bias that have been neglected: overlooking how auxiliary factors can impede LLM performance despite competence (auxiliary oversight), and dismissing LLM mechanistic strategies that differ from those of humans as not genuinely competent (mechanistic chauvinism). [...]

Sleep appears to modulate brain-wide neurofluid transport, encompassing the movement and exchange of cerebrospinal and interstitial fluids via perivascular pathways. However, neurofluid transport in common sleep disorders, such as insomnia disorder and obstructive sleep apnea, requires further assessment. [...]

The selective autophagy receptor p62/SQSTM1 is known to form higher-order filaments in vitro and to undergo liquid-liquid phase separation when mixed with poly-ubiquitin. Here, we determine the full-length cryo-EM structure of p62 and elucidate a structured double helical filament scaffold composed of the PB1-domain associated with the flexible C-terminal part and the solvent-accessible major groove. [...]