Open Access

The amyloid-β peptide (Aβ), implicated in Alzheimer's disease, exhibits significant polymorphism. At the monomer level, Aβ can adopt disordered, helical, and β-hairpin structures, influenced by environmental conditions. [...]

DNA enzymes, also known as DNAzymes (Dz), are synthetic high-precision biocatalysts that have been identified by in vitro selection three decades ago.1 Dz are usually short, single-stranded DNA molecules that catalyse chemical reactions through their specific three-dimensional structure.2 Due to their enormous therapeutic potential, particular interest has been invested in RNA-cleaving Dz, such as the 8–17 Dz and 10–23 Dz2. In general, these DNAzymes share a modular architecture comprising a (conserved) catalytic loop sequence and adaptable substrate binding arm sequences that, following specific design guidelines, can be modified to bind virtually any given target RNA with high selectivity..

1. Dieter Vollhardt: Understanding Correlated Materials with Lattice Fermions in Infinite Dimensions, 2 [...]

The granular microstructure of metals evolves significantly during thermomechanical processing through viscoplastic deformation and recrystallization. Microstructural features such as grain boundaries, subgrains, localized deformation bands, and non-uniform dislocation distributions critically influence grain nucleation and growth during recrystallization. [...]