Open Access

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A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration associated with soluble oligomeric and fibrillar forms of misfolded α-synuclein (α-syn). In this study, all-D-enantiomeric peptide ligands are presented that bind monomeric α-syn with high affinity, stabilize its physiological monomeric status, prevent aggregation and dissolve existing aggregates. [...]

Safeguarding water resources for society and ecosystems requires a comprehensiveunderstanding of hydrological fluxes within the Critical Zone, Earth's living skin where the atmosphere,hydrosphere, biosphere, and lithosphere meet. For decades, tracer‐aided mixing models have been used to trackwater flow paths through the Critical Zone, mapping the journey of water particles from atmospheric moisture togroundwater. [...]

Chikungunya virus (CHIKV) is an emerging pathogen affecting populations worldwide, with rapidly increasing infection rates. CHIKV, an arbovirus of the alphavirus genus, is predominantly found in tropical regions and transmitted by Aedes mosquitoes. [...]