Open Access

Ethylene (C2H4) regulates plant processes, such as germination, fruit ripening, and stress responses, impacting nutrition and food quality. The membrane-bound receptor ETR1 from Arabidopsis thaliana is a model for ethylene signaling, but both full-length and the soluble cytoplasmic domain have resisted crystallization. [...]

The viral rhodopsin 1 subfamily consists of microbial rhodopsins, such as VirChR1, with a light-gated cation channeling functionality, which is inhibited by calcium. For VirChR1, S14, E54, and N225 have been proposed as key residues for calcium binding. [...]

α-Synuclein (αSyn) is a key culprit in the pathogenesis of synucleinopathies such as Parkinson’s Disease (PD), in which it forms not only insoluble aggregates called amyloid fibrils but also smaller, likely more detrimental species termed oligomers. This property is shared with other amyloidogenic proteins such as the Alzheimer’s Disease-associated amyloid-β (Aβ). [...]

Multiple myeloma is a blood cancer characterized by plasma cell proliferation and excessive production of monoclonal proteins, often leading to renal complications and other forms of organ damage. A set of nine immunoglobulin free light chain (FLC) samples purified from urine of multiple myeloma patients was subjected to sedimentation velocity analysis. [...]

The economic competitiveness of bio-based production processes is often hindered by the high costs associated with downstream processing, compared to fossil-based methods. Liquid-liquid extraction is a widely used technique for aqueous fermentation systems and offers significant cost-saving potential, especially if extraction could be performed directly from the fermentation broth without prior cell separation. [...]

Reactive extraction is an attractive separation technology that can replace energy-intensive water evaporation steps in the industrial production of carboxylic acids. We systematically review the current literature on the extraction of low-value bioproducts and thereby identify the reduced availability of predictive models, limited selectivity, and challenging phase separation as possible bottlenecks in the industrial implementation of reactive extraction. [...]

Liquid-liquid gravity phase separation is crucial in chemical, biotechnological, metallurgical, and recycling processes. However, fluctuations in the feed stream conditions of the separator significantly affect the coalescence of dispersed drops, leading to the accumulation of a dense-packed zone (DPZ) and flooding. [...]

The industrial deployment of capture technologies for purifying gases with low partial pressure (e.g., flue gas) has been limited due to substantial economic hurdles. Process intensification offers a pathway to enhance the cost efficiency of sequestration. [...]