TY  - JOUR
AU  - Kuzkina, Anastasia
AU  - Panzer, Celine
AU  - Seger, Aline
AU  - Schmitt, Daniela
AU  - Rößle, Jonas
AU  - Schreglmann, Sebastian R.
AU  - Knacke, Henrike
AU  - Salabasidou, Elena
AU  - Kohl, Antonia
AU  - Sittig, Elisabeth
AU  - Barbe, Michael
AU  - Berg, Daniela
AU  - Volkmann, Jens
AU  - Sommer, Claudia
AU  - Oertel, Wolfgang H.
AU  - Schaeffer, Eva
AU  - Sommerauer, Michael
AU  - Janzen, Annette
AU  - Doppler, Kathrin
TI  - Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
JO  - Movement disorders
VL  - 38
IS  - 6
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - FZJ-2023-01616
SP  - mds.29340
PY  - 2023
AB  - ABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as anα-synucleinopathy.Methods:Skin  biopsies  of  patients  with  iRBD,Parkinson’s disease (PD), and controls were analyzedusing RT-QuIC and immunohistochemical detection ofphospho-α-synuclein.Results:α-Synuclein aggregation was detected in97.4% of iRBD patients (78.4% of iRBD biopsies),87.2% of PD patients (70% of PD biopsies), and 13%of controls (7.9% of control biopsies), with a higherseeding activity in iRBD compared to PD. RT-QuICwas  more  sensitive  but  less  specific  thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a sensitive methodto detectα-synuclein aggregation in iRBD, and highseeding activity may indicate a strong involvement ofdermal nervefibers in these patients. © 2023 TheAuthors.Movement   Disorderspublished by WileyPeriodicals LLC on behalf of International Parkinsonand Movement Disorder Society.Key Words:rapid eye movement sleep behavior dis-order;α-synuclein;  Parkinson’s  disease;  real-timequaking-induced conversion; skin biopsy
LB  - PUB:(DE-HGF)16
C6  - 36750755
UR  - <Go to ISI:>//WOS:000930736600001
DO  - DOI:10.1002/mds.29340
UR  - https://juser.fz-juelich.de/record/1005762
ER  -