Preprint

FZJ-2023-01831

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparing apples to apples -- Using a modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets

Gutzen, R. (Corresponding author)FZJ*RWTH* ; De Bonis, G. ; De Luca, C. ; Pastorelli, E. ; Capone, C. ; Mascaro, A. L. A. ; Resta, F. ; Manasanch, A. ; Pavone, F. S. ; Sanchez-Vives, M. V. ; Mattia, M. ; Grün, S.FZJ*RWTH* ; Paolucci, P. S. ; Denker, M.FZJ*

2022
arXiv

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Please use a persistent id in citations: http://hdl.handle.net/2128/34376  doi:10.48550/arXiv.2211.08527  doi:10.48550/ARXIV.2211.08527

Abstract: Neuroscience is moving towards a more integrative discipline, where understanding brain function requires consolidating the accumulated evidence seen across experiments, species, and measurement techniques. A remaining challenge on that path is integrating such heterogeneous data into analysis workflows such that consistent and comparable conclusions can be distilled as an experimental basis for models and theories. Here, we propose a solution in the context of slow wave activity (< 1 Hz), which occurs during unconscious brain states like sleep and general anesthesia, and is observed across diverse experimental approaches. We address the issue of integrating and comparing heterogeneous data by conceptualizing a general pipeline design that is adaptable to a variety of inputs and applications. Furthermore, we present the Collaborative Brain Wave Analysis Pipeline (Cobrawap) as a concrete, reusable software implementation to perform broad, detailed, and rigorous comparisons of slow wave characteristics across multiple, openly available ECoG and calcium imaging datasets.

Keyword(s): Neurons and Cognition (q-bio.NC) ; Quantitative Methods (q-bio.QM) ; FOS: Biological sciences

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Computational and Systems Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5235 - Digitization of Neuroscience and User-Community Building (POF4-523) (POF4-523)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. Algorithms of Adaptive Behavior and their Neuronal Implementation in Health and Disease (iBehave-20220812) (iBehave-20220812)

Appears in the scientific report 2023

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Database coverage:

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