Journal Article

FZJ-2023-04522

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity

Saberi, A.FZJ* ; Paquola, C.FZJ* ; Wagstyl, K. ; Hettwer, M. D.FZJ* ; Bernhardt, B. C. ; Eickhoff, S. B.FZJ* ; Valk, S. L. (Corresponding author)FZJ*

2023
PLoS Lawrence, KS

This record in other databases:      

Please use a persistent id in citations: doi:10.1371/journal.pbio.3002365  doi:10.34734/FZJ-2023-04522

Abstract: The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps of the 6 cortical layers based on 3D human brain histology, we aimed to quantitatively characterize the systematic covariation of laminar structure in the cortex and its functional consequences. After correcting for the effect of cortical curvature, we identified a spatial pattern of changes in laminar thickness covariance from lateral frontal to posterior occipital regions, which differentiated the dominance of infra- versus supragranular layer thickness. Corresponding to the laminar regularities of cortical connections along cortical hierarchy, the infragranular-dominant pattern of laminar thickness was associated with higher hierarchical positions of regions, mapped based on resting-state effective connectivity in humans and tract-tracing of structural connections in macaques. Moreover, we show that regions with similar laminar thickness patterns have a higher likelihood of structural connections and strength of functional connections. In sum, here, we characterize the organization of laminar thickness in the human isocortex and its association with cortico-cortical connectivity, illustrating how laminar organization may provide a foundational principle of cortical function.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2023

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---