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| Home > Publications database > Editorial: Combining computational and experimental approaches to characterize ion channels and transporters |
| Journal Article | FZJ-2024-00723 |
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2023
Frontiers Research Foundation
Lausanne
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Please use a persistent id in citations: doi:10.3389/fphys.2023.1320336 doi:10.34734/FZJ-2024-00723
Abstract: Electrical signaling plays a major role in a variety of cellular functions. It is fast, wellsuited for coding information and is—because of the low dielectric constant of biologicalmembranes—very energy-efficient. In living systems, ion channels and transportersdetermine electrical signals in a cooperative fashion. Transporters generate ion gradients,and ion channels utilize these gradients by mediating large ion fluxes that quickly charge themembrane capacitor and change voltages across the membrane. The importance of ionchannels in excitable tissues has been known for many decades. The invention of patchclamping made a broad variety of cells accessible to cell electrophysiology; such experimentsdemonstrated the importance of electrical signaling also in many non-excitable cells over thehuman body.Because of their widespread importance, ion channels and transporters have beenintensively studied in the recent past. Currently, we have reached a solid understanding ofthe function of many ion channels and transporters, and we possess knowledge of the three-dimensional structures for most of them. Simultaneously, computational biology tools nowenable us to link structure dynamics to transport functions. This rapid progress inunderstanding these class of membrane proteins prepares us for the next step, to usechannel and transport function to predict ion concentrations and membrane potentials incell organelles and cell compartments, towards an atomistic understanding of cell function.To link channel and transporter structure to protein function and even more to thebehavior of subcellular and cellular systems, experiments need to be combined withcomputational approaches. Our Research Topic Combining Computational andExperimental Approaches to Characterize Ion Channels and Transporters, has the aim topresent recent progress and findings achieved through the application of such acombination. It encompasses eight publications that combine experiments andcomputational work to describe the function of various ion channels and transporters.
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