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| Hauptseite > Publikationsdatenbank > Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis |
| Hauptseite > Publikationsdatenbank > Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis |
| Journal Article | FZJ-2024-01699 |
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2024
Elsevier
[New York, NY]
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Please use a persistent id in citations: doi:10.1016/j.celrep.2024.113770 doi:10.34734/FZJ-2024-01699
Abstract: Cerebellar involvement in both motor and non-motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.Keywords: CP: Neuroscience; brain evolution; functional hierarchy; gene expression; human cerebellum; neuropsychiatric disorder.
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