Journal Article

FZJ-2024-03585

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Rituximab in non-systemic vasculitic neuropathy: a single-center experience

Kohle, F. (Corresponding author) ; Wunderlich, G. ; Fink, G. R.FZJ* ; Schroeter, M. ; Lehmann, H. C. ; Schneider, C.

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00415-024-12378-1  doi:10.34734/FZJ-2024-03585

Abstract: Objectives This case series reports clinical features and outcome of four patients with non-systemic vasculitic neuropathy(NSVN) treated with the anti-CD20 agent rituximab.Methods Clinical, electrophysiological and biopsy data were retrospectively obtained and evaluated. Only patients withpathological definite or probable NSVN were included. Extensive clinical and laboratory work-up excluded systemic vasculitis.Follow-up data for at least 12 months and up to five years is provided. Outcome of the patients was assessed usingthe MRC-Sum Score, Prineas Score and Neurological Symptom Score.Results Two of four patients treated with rituximab achieved disease remission and one patient remained stable under anti-CD20 therapy after a required treatment switch due to toxic side effects of cyclophosphamide. One patient deteriorated underrituximab induction. Rituximab was well tolerated in all patients.Discussion Anti-CD20 therapy might be an alternative in NSVN patients requiring further treatment escalation or treatmentswitch due to side effects of corticosteroids or cyclophosphamide.

Note: Funding Open Access funding enabled and organized by Projekt DEAL. FK was supported by the Cologne Clinician Scientist Program (CCSP)/Faculty of Medicine/University of Cologne. Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (Project No. 413543196).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. DFG project 413543196 - Kölner Clinician Scientist Programm (413543196) (413543196)

Appears in the scientific report 2024

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