Dataset

FZJ-2024-07293

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regional and laminar distribution of receptors for GABA in the rat brain (v2)

Zhao, L.FZJ* ; Zilles, K. ; Palomero-Gallagher, N. (Corresponding author)FZJ* ; Puchades, M. A. (Corresponding author)

2024
EBRAINS

This record in other databases:

Please use a persistent id in citations: doi:10.25493/3E5S-9QK

Abstract: The present dataset provides the quantitative regional and laminar distribution of key molecules of inhibitory neurotransmission, namely the γ-aminobutyric acid (GABA) receptors GABA A and GABA B as well as the peripheral benzodiazepine (perBZ) receptors and the GABA A associated benzodiazepine (GABA A /BZ) binding sites, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands muscimol, CGP 54626 and flumazenil. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as the hippocampal regions and layers, or subcortical structures such as amygdalar nuclei. We also provide information about image data registration to the Waxholm Sprague Dawley rat brain atlas.

Keyword(s): Neuroscience

---

Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health (101147319) (101147319)

Appears in the scientific report 2024

---