Journal Article

FZJ-2024-07307

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies

Tamon, H. ; Fujino, J. ; Itahashi, T. ; Frahm, L. (Corresponding author)FZJ*RWTH* ; Parlatini, V. ; Aoki, Y. Y. ; Castellanos, F. X. ; Eickhoff, S. B.FZJ* ; Cortese, S.

2024
HighWire Press Stanford, Calif.

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Please use a persistent id in citations: doi:10.1176/appi.ajp.20230270  doi:10.34734/FZJ-2024-07307

Abstract: Objective:To investigate shared and specific neural correlates of cognitive functions in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), the authors performed a comprehensive meta-analysis and considered a balanced set of neuropsychological tasks across the two disorders.Methods:A broad set of electronic databases was searched up to December 4, 2022, for task-based functional MRI studies investigating differences between individuals with ADHD or ASD and typically developing control subjects. Spatial coordinates of brain loci differing significantly between case and control subjects were extracted. To avoid potential diagnosis-driven selection bias of cognitive tasks, the tasks were grouped according to the Research Domain Criteria framework, and stratified sampling was used to match cognitive component profiles. Activation likelihood estimation was used for the meta-analysis.Results:After screening 20,756 potentially relevant references, a meta-analysis of 243 studies was performed, which included 3,084 participants with ADHD (676 females), 2,654 participants with ASD (292 females), and 6,795 control subjects (1,909 females). ASD and ADHD showed shared greater activations in the lingual and rectal gyri and shared lower activations in regions including the middle frontal gyrus, the parahippocampal gyrus, and the insula. By contrast, there were ASD-specific greater and lower activations in regions including the left middle temporal gyrus and the left middle frontal gyrus, respectively, and ADHD-specific greater and lower activations in the amygdala and the global pallidus, respectively.Conclusions:Although ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.

Note: This work was partly supported by the Japan Society for the Promotion of Science (grant 21K15719 to Dr. Aoki) and the Japan Agency for Medical Research and Development (grant JP18dm0307008). Dr. Eickhoff was supported by the European Union’s Horizon 2020 Research and Innovation Program (grants 945539 [HBP SGA3] and 826421 [VBC]), the Deutsche Forschungsgemeinschaft (DFG, SFB 1451; and IRTG 2150), and NIH (grant R01MH074457). Dr. Cortese was supported by a National Institute for Health and Care Research (NIHR) Research Professorship (grant NIHR303122), by NIHR grants NIHR203684, NIHR203035, NIHR130077, NIHR128472, and RP-PG-0618-20003, and by European Research Executive Agency grant 101095568-HORIZONHLTH-2022-DISEASE-07-03.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. DFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2024

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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