Dataset

FZJ-2024-07308

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regional and laminar distribution of dopamine receptors and uptake sites in the rat brain (v2)

Zhao, L.FZJ* ; Puchades, M. A. (Corresponding author) ; Zilles, K. ; Palomero-Gallagher, N. (Corresponding author)FZJ*

2024
EBRAINS

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Please use a persistent id in citations: doi:10.25493/5Z1Y-TNB

Abstract: The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the dopamine receptors D 1 and D 2 , as well as the dopamine uptake sites in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands SCH 23390, racloprid and mazindol. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as the hippocampal regions and layers, or subcortical structures such as amygdalar nuclei. We also provide information about image data registration to the Waxholm Sprague Dawley rat brain atlas.

Keyword(s): Neuroscience

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health (101147319) (101147319)

Appears in the scientific report 2024

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