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| Hauptseite > Publikationsdatenbank > Exploring dilution effects on Pluronic® P103 micelles: Structural insights |
| Hauptseite > Publikationsdatenbank > Exploring dilution effects on Pluronic® P103 micelles: Structural insights |
| Journal Article | FZJ-2025-01987 |
; ; ; ;
2025
Elsevier
New York, NY [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.molliq.2024.126779
Abstract: The study examines the impact of dilution on the stability of Pluronic® P103 micelles. It thoroughly explores the consequences of dilution on micellar size, providing essential insights into their behavior under physiological conditions. The salt and polymer concentrations were simultaneously varied at different ratios to analyze their effects. Techniques such as cloud point, small-angle neutron scattering (SANS), dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy and high-performance liquid chromatography (HPLC) were employed to check the influence of dilution on the phase behaviour, size and structure of micellar self-assembly, interaction and encapsulation efficiency for the hydrophobic anti-inflammatory drug, ibuprofen, respectively. The results showed that increased polymer and salt concentration led to synergistic effects influencing nanostructure formation. The presence of salt significantly influences micellar size, and the encapsulation potential of the micelles for the drug. This study enhances our fundamental understanding of these polymer-salt systems and has potential implications for tailoring nanostructures with precise control over their properties. These findings are significant in drug delivery and materials science fields, offering opportunities for designing customized nanostructures for various applications.
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