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001044419 1001_ $$0P:(DE-Juel1)145832$$aGordjinejad, Ali$$b0$$eCorresponding author
001044419 245__ $$aHemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine
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001044419 520__ $$aThe human brain exhibits asymmetric hemispheric activity at night; this plays acrucial role in cognitive impairment from sleep deprivation. Although there havebeen many investigations on this topic, there are no studies on hemisphericdifferences in the consumption of high-energy phosphates (HEP). We presenthere a new data analysis of our previously published study in which subjects weremeasured for changes in high-energy phosphate (HEP), tCr/tNAA, and Glu/TNAAduring subacute sleep deprivation (21 h) and cognitive tests. In our new analysis,we investigated differences and asymmetries in the metabolic consumption ofboth hemispheres. Comprehensive per-individual voxel-wise interhemisphericcomparisons at all time points and conditions showed a greater decrease frombaseline of ATP in the right than in the left hemisphere. Partial volume correctionyielded an apparent higher decline of PCr/Pi in gray versus white matter. We alsoinvestigated whether creatine supplementation, which has been shown to preventcognitive impairment during sleep deprivation, affected this hemispheric asymmetry.In a second session, the subjects took a high single dose of creatine monohydratesuspension (0.35 g/kg) after baseline measurements. Creatine balanced the sleepdeprivation-induced asymmetry to a higher degree in the left hemisphere, whichwas due to an increase in PCr/Pi and decrease in ATP. Our results confirm—viathe observed decrease in ATP level—a night-active right hemisphere. Creatineadministration balanced this asymmetry.
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001044419 7001_ $$0P:(DE-Juel1)138474$$aMatusch, Andreas$$b1$$ufzj
001044419 7001_ $$0P:(DE-HGF)0$$aKleedörfer, Sophie$$b2
001044419 7001_ $$0P:(DE-HGF)0$$aPatel, Harshal Jayeshkumar$$b3
001044419 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b4$$ufzj
001044419 7001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b5$$ufzj
001044419 7001_ $$0P:(DE-Juel1)142495$$aBinkofski, Ferdinand$$b6$$ufzj
001044419 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b7$$ufzj
001044419 773__ $$0PERI:(DE-600)2411902-7$$a10.3389/fnins.2025.1515761$$gVol. 19, p. 1515761$$p1515761$$tFrontiers in neuroscience$$v19$$x1662-4548$$y2025
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