Journal Article

FZJ-2025-03182

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine

Gordjinejad, A. (Corresponding author)FZJ* ; Matusch, A.FZJ* ; Kleedörfer, S. ; Patel, H. J. ; Drzezga, A.FZJ* ; Elmenhorst, D.FZJ* ; Binkofski, F.FZJ* ; Bauer, A.FZJ*

2025
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnins.2025.1515761

Abstract: The human brain exhibits asymmetric hemispheric activity at night; this plays acrucial role in cognitive impairment from sleep deprivation. Although there havebeen many investigations on this topic, there are no studies on hemisphericdifferences in the consumption of high-energy phosphates (HEP). We presenthere a new data analysis of our previously published study in which subjects weremeasured for changes in high-energy phosphate (HEP), tCr/tNAA, and Glu/TNAAduring subacute sleep deprivation (21 h) and cognitive tests. In our new analysis,we investigated differences and asymmetries in the metabolic consumption ofboth hemispheres. Comprehensive per-individual voxel-wise interhemisphericcomparisons at all time points and conditions showed a greater decrease frombaseline of ATP in the right than in the left hemisphere. Partial volume correctionyielded an apparent higher decline of PCr/Pi in gray versus white matter. We alsoinvestigated whether creatine supplementation, which has been shown to preventcognitive impairment during sleep deprivation, affected this hemispheric asymmetry.In a second session, the subjects took a high single dose of creatine monohydratesuspension (0.35 g/kg) after baseline measurements. Creatine balanced the sleepdeprivation-induced asymmetry to a higher degree in the left hemisphere, whichwas due to an increase in PCr/Pi and decrease in ATP. Our results confirm—viathe observed decrease in ATP level—a night-active right hemisphere. Creatineadministration balanced this asymmetry.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2025

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