TY  - JOUR
AU  - Gordjinejad, Ali
AU  - Matusch, Andreas
AU  - Kleedörfer, Sophie
AU  - Patel, Harshal Jayeshkumar
AU  - Drzezga, Alexander
AU  - Elmenhorst, David
AU  - Binkofski, Ferdinand
AU  - Bauer, Andreas
TI  - Hemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine
JO  - Frontiers in neuroscience
VL  - 19
SN  - 1662-4548
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2025-03182
SP  - 1515761
PY  - 2025
AB  - The human brain exhibits asymmetric hemispheric activity at night; this plays acrucial role in cognitive impairment from sleep deprivation. Although there havebeen many investigations on this topic, there are no studies on hemisphericdifferences in the consumption of high-energy phosphates (HEP). We presenthere a new data analysis of our previously published study in which subjects weremeasured for changes in high-energy phosphate (HEP), tCr/tNAA, and Glu/TNAAduring subacute sleep deprivation (21 h) and cognitive tests. In our new analysis,we investigated differences and asymmetries in the metabolic consumption ofboth hemispheres. Comprehensive per-individual voxel-wise interhemisphericcomparisons at all time points and conditions showed a greater decrease frombaseline of ATP in the right than in the left hemisphere. Partial volume correctionyielded an apparent higher decline of PCr/Pi in gray versus white matter. We alsoinvestigated whether creatine supplementation, which has been shown to preventcognitive impairment during sleep deprivation, affected this hemispheric asymmetry.In a second session, the subjects took a high single dose of creatine monohydratesuspension (0.35 g/kg) after baseline measurements. Creatine balanced the sleepdeprivation-induced asymmetry to a higher degree in the left hemisphere, whichwas due to an increase in PCr/Pi and decrease in ATP. Our results confirm—viathe observed decrease in ATP level—a night-active right hemisphere. Creatineadministration balanced this asymmetry.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.3389/fnins.2025.1515761
UR  - https://juser.fz-juelich.de/record/1044419
ER  -