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@ARTICLE{Gordjinejad:1044419,
      author       = {Gordjinejad, Ali and Matusch, Andreas and Kleedörfer,
                      Sophie and Patel, Harshal Jayeshkumar and Drzezga, Alexander
                      and Elmenhorst, David and Binkofski, Ferdinand and Bauer,
                      Andreas},
      title        = {{H}emispheric asymmetry in high-energy phosphate
                      consumption during sleep-deprivation is balanced by
                      creatine},
      journal      = {Frontiers in neuroscience},
      volume       = {19},
      issn         = {1662-4548},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2025-03182},
      pages        = {1515761},
      year         = {2025},
      abstract     = {The human brain exhibits asymmetric hemispheric activity at
                      night; this plays acrucial role in cognitive impairment from
                      sleep deprivation. Although there havebeen many
                      investigations on this topic, there are no studies on
                      hemisphericdifferences in the consumption of high-energy
                      phosphates (HEP). We presenthere a new data analysis of our
                      previously published study in which subjects weremeasured
                      for changes in high-energy phosphate (HEP), tCr/tNAA, and
                      Glu/TNAAduring subacute sleep deprivation (21 h) and
                      cognitive tests. In our new analysis,we investigated
                      differences and asymmetries in the metabolic consumption
                      ofboth hemispheres. Comprehensive per-individual voxel-wise
                      interhemisphericcomparisons at all time points and
                      conditions showed a greater decrease frombaseline of ATP in
                      the right than in the left hemisphere. Partial volume
                      correctionyielded an apparent higher decline of PCr/Pi in
                      gray versus white matter. We alsoinvestigated whether
                      creatine supplementation, which has been shown to
                      preventcognitive impairment during sleep deprivation,
                      affected this hemispheric asymmetry.In a second session, the
                      subjects took a high single dose of creatine
                      monohydratesuspension (0.35 g/kg) after baseline
                      measurements. Creatine balanced the sleepdeprivation-induced
                      asymmetry to a higher degree in the left hemisphere,
                      whichwas due to an increase in PCr/Pi and decrease in ATP.
                      Our results confirm—viathe observed decrease in ATP
                      level—a night-active right hemisphere.
                      Creatineadministration balanced this asymmetry.},
      cin          = {INM-2 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3389/fnins.2025.1515761},
      url          = {https://juser.fz-juelich.de/record/1044419},
}