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| 100 | 1 | _ | |a Gordjinejad, Ali |0 P:(DE-Juel1)145832 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Hemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine |
| 260 | _ | _ | |a Lausanne |c 2025 |b Frontiers Research Foundation |
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| 520 | _ | _ | |a The human brain exhibits asymmetric hemispheric activity at night; this plays acrucial role in cognitive impairment from sleep deprivation. Although there havebeen many investigations on this topic, there are no studies on hemisphericdifferences in the consumption of high-energy phosphates (HEP). We presenthere a new data analysis of our previously published study in which subjects weremeasured for changes in high-energy phosphate (HEP), tCr/tNAA, and Glu/TNAAduring subacute sleep deprivation (21 h) and cognitive tests. In our new analysis,we investigated differences and asymmetries in the metabolic consumption ofboth hemispheres. Comprehensive per-individual voxel-wise interhemisphericcomparisons at all time points and conditions showed a greater decrease frombaseline of ATP in the right than in the left hemisphere. Partial volume correctionyielded an apparent higher decline of PCr/Pi in gray versus white matter. We alsoinvestigated whether creatine supplementation, which has been shown to preventcognitive impairment during sleep deprivation, affected this hemispheric asymmetry.In a second session, the subjects took a high single dose of creatine monohydratesuspension (0.35 g/kg) after baseline measurements. Creatine balanced the sleepdeprivation-induced asymmetry to a higher degree in the left hemisphere, whichwas due to an increase in PCr/Pi and decrease in ATP. Our results confirm—viathe observed decrease in ATP level—a night-active right hemisphere. Creatineadministration balanced this asymmetry. |
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| 773 | _ | _ | |a 10.3389/fnins.2025.1515761 |g Vol. 19, p. 1515761 |0 PERI:(DE-600)2411902-7 |p 1515761 |t Frontiers in neuroscience |v 19 |y 2025 |x 1662-4548 |
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