Journal Article

FZJ-2025-04521

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png 3D-manufactured non-isothermal glass cell for thermophoretic measurements

Lee, N. (Corresponding author) ; Wiegand, S. (Corresponding author)FZJ*

2026
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.applthermaleng.2025.128994

Abstract: Thermophoresis, the migration of particles within a thermal gradient, presents opportunities in diverse fields ranging from biotechnology to energy applications. The quantification of this phenomenon, described by the Soret coefficient (S_T), requires precise control over non-isothermal conditions, which is challenging to achieve in conventional microfluidic devices. However, conventional polymer-based cells are limited by a significant temperature drop across the material and susceptibility to the adhesion of colloidal particles. Recently, 3D-manufactured glass cells have been shown to produce a non-isothermal temperature field in a microchannel for inducing a significant temperature gradient due to high thermal conductivity, which enables temperature-dependent analysis of thermophoresis. Herein, we present a 3D-manufactured glass microfluidic cell for measuring the Soret coefficient under controlled temperature gradients. The cell produces a stable and a large temperature gradient across the channel which allows multi-temperature measurements without adjusting hot and cold water temperatures. The measured Soret coefficient by the glass cell across a temperature range of 20 °C to 30 °C shows close agreement with the benchmark measurement data. These results show that the 3D-manufactured glass cell can not only quantify the Soret coefficient but can also function as a solvent-resistant device, suitable for complex biological and chemical solutions.

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Contributing Institute(s):

1. Biomakromolekulare Systeme und Prozesse (IBI-4)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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