Poster (After Call)

FZJ-2025-05865

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Resolving inconsistent effects of tDCS on learning using a homeostatic structural plasticity model

Lu, H. (Corresponding author)FZJ* ; Frase, L. ; Normann, C. ; Rotter, S.

2025

Abstract: Transcranial direct current stimulation (tDCS) is increasingly used to modulate motor learning. Current polarity and intensity,electrode montage, and application before or during learning had mixed effects. Both Hebbian and homeostatic plasticity were proposed toaccount for the observed effects, but the explanatory power of these models is limited. In a previous modeling study, we showed thathomeostatic structural plasticity (HSP) can explain long-lasting after-effects of tDCS and transcranial magnetic stimulation (TMS).Results: The interference between motor learning and tDCS, which are both based on HSP in our model, is a candidatemechanism to resolve complex and seemingly contradictory experimental observations.

---

Contributing Institute(s):

1. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)
2. SLNS - SimLab Neuroscience (Helmholtz-SLNS) (Helmholtz-SLNS)
3. JL SMHB - Joint Lab Supercomputing and Modeling for the Human Brain (JL SMHB-2021-2027) (JL SMHB-2021-2027)

---