Journal Article

FZJ-2026-02559

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Wearable Movement‐Tracking for Prodromal Parkinson's Disease Detection: A Cross‐Country Validation Study

Kahl, F. ; Schalkamp, A.-K. ; Gunter, K. M. ; Ophey, A. ; Röttgen, S.FZJ* ; Razzaque, J. ; Kufer, K. ; Sandor, C. ; Fink, G. R.FZJ* ; Kalbe, E. ; Maetzler, W. ; Hansen, C. ; Jonas, S. M. ; Hu, M. T. ; Reimer, L. M. (Corresponding author) ; Sommerauer, M. (Corresponding author)FZJ*

2026
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.70329  doi:10.34734/FZJ-2026-02559

Abstract: B R I E F R E P O R TWearable Movement-Tracking for Prodromal Parkinson’s DiseaseDetection: A Cross-Country Validation StudyFabian Kahl, MSc, 1 Ann-Kathrin Schalkamp, PhD,2,3,4 Katarina Mary Gunter, MSc, 5 Anja Ophey, PhD,6,7Sinah Röttgen, MSc, 7,8 Jamil Razzaque, MSc,5 Konstantin Kufer, MSc, 9,10 Cynthia Sandor, PhD,3,4Gereon R. Fink, MD, 7,8 Elke Kalbe, PhD,6 Walter Maetzler, MD, 11 Clint Hansen, PhD, 11 Stephan M. Jonas, PhD,1Michele T. Hu, MBBS, MRCP, PhD,5 Lara Marie Reimer, PhD,1 * and Michael Sommerauer, MD7,8,9,10*A B S T R A C T : Background: Models trained on acceler-ometer data have been proposed for detecting prodro-mal Parkinson’s disease (PD). However, uncertainties indiagnosis timing in the UK Biobank (UKBB) may affectgeneralizability to other cohorts.Objectives: The aim of the study was to evaluate theperformance of previously published models for prodro-mal PD detection in other international cohorts.Methods: We applied the models to data from Germanand British cohorts of individuals with isolated or idio-pathic rapid eye movement sleep behavior disorder andhealthy controls. We compared hourly acceleration pat-terns and classification performance across cohorts.Results: The British cohort exhibited visually similaractivity patterns to UK Biobank but weaker statistical dif-ferences and reduced model performance. The Germancohort showed no significant group differences andlower performance. No pair of cohorts demonstrated sta-tistical equivalence.Conclusions: Models trained on UK Biobank data maycapture early clinical disease rather than universalprodromal markers. Prospective validation in well-characterized cohorts is essential before clinical translation.© 2026 The Author(s). Movement Disorders published byWiley Periodicals LLC on behalf of International Parkinsonand Movement Disorder Society

Note: This study was supported by public and institu-tional research funding, including support from the German FederalMinistry of Education and Research (via the NDEMobil/Junior ResearchGroup and related programs), the Ministry of Culture and Science of theState of North Rhine-Westphalia (iBehave network), the Koeln FortuneProgram (Faculty of Medicine, University of Cologne), the NIHR OxfordBiomedical Research Centre, the “Netzwerke 2021” program and Fed-eral Ministry funding (FKZ: 01EO2107), EU Horizon Europe(ERA4Health, GA no. 101095426), and a European Research Councilaward (ID 10116958)

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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