Journal Article

FZJ-2026-04878

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Primary central nervous system lymphoma—current standards and recent developments

Van Der Meulen, M. (Corresponding author) ; Vermaat, J. S. P. ; Galldiks, N.FZJ* ; Issa, S. ; De Bresser, J. ; Doorduijn, J. K. ; Bromberg, J. E. C.

2026
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/nop/npag016  doi:10.34734/FZJ-2026-04878

Abstract: Primary central nervous system lymphoma (PCNSL) is a rare aggressive B-cell non-Hodgkin lymphoma confined to the central nervous system, without systemic involvement. The incidence has increased over the past 3 decades. The prognosis has improved in patients up to 70 years old, and this type of lymphoma can be potentially cured. The gold standard of diagnosing PCNSL is histological, usually on a brain biopsy specimen via a neurosurgical procedure. Recent developments in both imaging and laboratory analyses of the cerebrospinal fluid, can be helpful in narrowing the differential diagnosis, diagnosing PCNSL itself, and in follow-up after treatment. This narrative review gives an overview of the epidemiology, diagnosis, and treatment of PCNSL, with an emphasis on recent developments in diagnostic techniques and treatment.Keywords: Imaging|, liquid biopsy, MRI, [18F]FDG-PET, treatment

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Emerging Sources Citation Index ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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