Journal Article

PreJuSER-11284

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping

Amunts, K.FZJ* ; Lenzen, M.FZJ* ; Friederici, A. D. ; Schleicher, A. ; Morosan, P.FZJ* ; Palomero-Gallagher, N.FZJ* ; Zilles, K.FZJ*

2010
PLoS Lawrence, KS

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Please use a persistent id in citations: doi:10.1371/journal.pbio.1000489

Abstract: There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.

Keyword(s): Animals (MeSH) ; Autoradiography (MeSH) ; Frontal Lobe: metabolism (MeSH) ; Humans (MeSH) ; Receptors, Cell Surface: metabolism (MeSH) ; Receptors, Cell Surface ; J

Note: This work was supported by the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (AF), the Bundesministerium fur Bildung und Forschung (01GW0771, 01GW0623; KA), and the Deutsche Forschungsgemeinschaft (AM 118/1-2). The study was partially supported by the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (KZ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. BMBF-01GW0771 - Neuroanatomische Kartierung des frontalen Operculums (BMBF-01GW0771) (BMBF-01GW0771)
3. BMBF-01GW0623 - Anatomische Basis von Prosodie und Gesang (BMBF-01GW0623) (BMBF-01GW0623)
4. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2010

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