Book	PreJuSER-136045

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Von Chorismat abgeleitete funktionalisierte Cyclohexadiene

Lorbach, V. (Corresponding author)FZJ*

2007
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag Jülich
ISBN: 3-89336-500-1, 978-3-89336-500-5

This record in other databases:

Please use a persistent id in citations: http://hdl.handle.net/2128/3099

Abstract: Nature is up to the present the most important source for chiral non-racemic building blocks ($\textit{chiral pool}$ compounds). Chorismate and related functionalized cyclohexadienes are interesting starting materials for chemical syntheses due to their high degree of functionalization. Microbial access to the $\beta$-amino acid 2,3-$\textit{trans}$-CHA was established by homologous expression of anthranilate synthase (TrpE$^{H398M}$), which was created by site-directed mutagenesis, and PhzD, an enzyme of the phenazine biosynthesis. [figure] 2,3-$\textit{trans}$-CHA and other functionalized cyclohexadienes were isolated in gram scale and high purity by different methods. The potential of functionalized cyclohexadienes for organic synthesis was predominantly demonstrated in the case of 2,3-$\textit{trans}$-CHD by different reaction types as well as natural product syntheses. [figure]

Note: Record converted from JUWEL: 18.07.2013
Note: Universität Bonn, Diss., 2005

---

Contributing Institute(s):

1. Institut für Biotechnologie (IBT)

Appears in the scientific report 2013

---

Database coverage:

---