Journal Article

FZJ-2013-04574

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Generation of Protein Nanogradients by Microcontact Printing4

Schwaab, D.FZJ* ; Zentis, P.FZJ* ; Winter, S.FZJ* ; Meffert, S.FZJ* ; Offenhäusser, A.FZJ* ; Mayer, D. (Corresponding author)FZJ*

2013
Inst. of Pure and Applied Physics Tokyo

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Please use a persistent id in citations: doi:10.7567/JJAP.52.05DA19

Abstract: High resolution lithography combined with microcontact printing (µCP) by means of polyolefine polymer (POP) stamps enabled to create protein gradient patterns. By this means, discrete purely biochemical gradients of extracellular matrix proteins were fabricated. It was possible to adjust independently both the size of elements of a protein pattern and the distance between them with sub 100 nm resolution. Adhesion of primary neurons and directed neuronal outgrowth were observed on these protein patterns. Cellular constituents such as filopodia adhere to different printed protein elements of the discontinuous gradient including features as small as 75 nm.

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Contributing Institute(s):

1. Bioelektronik (ICS-8)
2. Bioelektronik (PGI-8)
3. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. 423 - Sensorics and bioinspired systems (POF2-423) (POF2-423)
2. 453 - Physics of the Cell (POF2-453) (POF2-453)

Appears in the scientific report 2013

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Database coverage:
; Current Contents - Social and Behavioral Sciences ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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