Journal Article

PreJuSER-15880

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Improved NiSi0.8Ge0.2/Si0.8Ge0.2 Contacs by C+ Pre-Implantation

Zhang, B.FZJ* ; Yu, W.FZJ* ; Zhao, Q. T.FZJ* ; Buca, D.FZJ* ; Holländer, B.FZJ* ; Hartmann, J. M. ; Zhang, M. ; Wang, X. ; Mantl, S.FZJ*

2011
Soc. Pennington, NJ

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Please use a persistent id in citations: doi:10.1149/1.3578387

Abstract: This open-label extension evaluated the long-term efficacy and tolerability of rufinamide in patients with Lennox-Gastaut syndrome (LGS) who had previously completed a 12-week double-blind study.In total, 124 patients (aged 4-37 years), receiving 1-3 concomitant antiepileptic drugs, were treated with rufinamide approximately 25-60 mg/kg/day. Efficacy was assessed by seizure frequency; tolerability by adverse events (AEs) and laboratory tests.Overall, patients were treated with rufinamide for a median (range) of 432 (10-1149) days. Reductions in seizure frequency were observed throughout the study; during the last 12 months of treatment, 41.0% and 47.9% of patients had > or = 50% reduction in total and tonic-atonic seizure frequency, respectively. The most common AEs were vomiting (30.6%) and pyrexia (25.8%).In this open-label extension, rufinamide appeared to be an effective long-term adjunctive therapy for the treatment of LGS-associated seizures in children and young adults.

Keyword(s): J

Note: This work was supported by the German Federal Ministry of Education and Research via the MEDEA+ project DECI-SIF(2T104). Additional funding was received by the Nanosil network from the European Community (FP7 grant No. 216171). B. Zhang thanks the National Natural Science Foundation of China under Grant No. 61006088 and, together with W. Yu to the China Scholarship Council for the financial support.

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Contributing Institute(s):

1. Halbleiter-Nanoelektronik (PGI-9)
2. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Grundlagen für zukünftige Informationstechnologien (P42)
2. NANOSIL - Silicon-based nanostructures and nanodevices for long term nanoelectronics applications (216171) (216171)

Appears in the scientific report 2011

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