Journal Article

PreJuSER-16488

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biomonitoring for arsenic, toxic and essential metals in single hair strands by laser ablation inductively coupled plasma mass spectrometry

Kumtabtim, U. ; Matusch, A.FZJ* ; Dani, S. U. ; Siripinyanond, A. ; Becker, J. S.FZJ*

2011
Elsevier Science [S.l.]

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Please use a persistent id in citations: doi:10.1016/j.ijms.2011.03.007

Abstract: Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been developed as reliable analytical technique for the quantitation of metal distributions at micrometre resolution. In this work a novel microanalytical strategy for biomonitoring of arsenic, toxic and essential metals in single hair strands is proposed. Two different calibration strategies in LA-ICP-MS were developed using either certified hair standard reference material (IAEA 086) or prepared matrix-matched laboratory hair standards doped with analytes of interest at defined concentration. Powdered hair standards and human hair strands mounted on a sticky tape in the LA chamber were analyzed under the same experimental conditions by an optimized LA-ICP-MS technique. The use of hair powder standard allows calibration curves to be obtained by plotting the analyte ion (M+) intensity normalized to S-34(+) (the ratio M+/S-34(+)) as a function of the concentration determined by ICP-MS of acidic digests. The linear correlation coefficients (R) of calibration curves for analytes As, Ba, Cd, Ce, Co, Cr, Cu, Fe, Ga, Hg, Mg, Mo, Ni, Pb, Rb, Sr, Ti and U were typically between 0.985 and 0.999. The limit of detection (LOD) was 0.6 mu g g(-1) for As and ranged from 0.3 to 7.8 mu g g(-1) for the other analytes. Distinct elemental exposition time profiles were observed in hair samples from five volunteers. (C) 2011 Elsevier B.V. All rights reserved.

Keyword(s): J ; Arsenic (auto) ; Biomonitoring (auto) ; Hair strand (auto) ; Laser ablation inductively coupled plasma mass spectrometry (auto) ; Metal distribution (auto)

Note: The authors would like to thank Thermo Scientific, Bremen for instrumental support for the Brain Met Centre and L. Terrier for providing hair samples. Usarat Kumtabtim would like to acknowledge the Office of Higher Education Commission (Thailand) for financial support of her research in the Brain Met laboratory at Forschungszentrum Julich (www.brainmet.com/).

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Contributing Institute(s):

1. Zentralabteilung für Chemische Analysen (ZCH)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2011

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