Journal Article

FZJ-2015-03687

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deep brain stimulation in the ventrolateral thalamus/subthalamic area in dystonia with head tremor

Pauls, K. A. M. (Corresponding Author) ; Hammesfahr, S. ; Moro, E. ; Moore, A. P. ; Binder, E.FZJ* ; El Majdoub, F. ; Fink, G. R.FZJ* ; Sturm, V. ; Krauss, J. K. ; Maarouf, M. ; Timmermann, L.

2014
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.25884

Abstract: BackgroundPallidal deep brain stimulation (GPi-DBS) effectively ameliorates idiopathic dystonia, although approximately 15% of patients respond insufficiently. Although various thalamic and subthalamic targets have been suggested for dystonic tremor, no systematic studies have been published on thalamic DBS in dystonic tremor. We assessed the effect of thalamic/subthalamic area DBS (Th-DBS) on dystonic head tremor and dystonia in a single-blind design.MethodsDystonic head tremor and dystonia before and 3 months after surgery were quantified via blinded video-ratings using the Fahn-Tolosa-Marin-Tremor-Scale and the Burke-Fahn-Marsden-Dystonia-Rating-Scale in seven patients with idiopathic cervical or segmental dystonia, dystonic head tremor, and bilateral Th-DBS. Pain, side effects, adverse events, and stimulation parameters were assessed.ResultsTh-DBS improved dystonic tremor and dystonia (P < 0.05; 57.1% and 70.4%, respectively). Head tremor amplitude and pain were also improved (P < 0.05; 77.5% and 90.0%, respectively). Side effects included dysarthria, gait disturbance, slowness of movement, and weight gain.ConclusionDystonic head tremor and dystonia can be improved with Th-DBS.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)

Appears in the scientific report 2015

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Database coverage:
; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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