Journal Article

FZJ-2015-03980

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Neutron Spin-Echo and TOF Reveals Protein Dynamics in Solution

Stadler, A. (Corresponding Author)FZJ* ; Monkenbusch, M. (Corresponding Author)FZJ* ; Biehl, R.FZJ* ; Richter, D.FZJ* ; Ollivier, J.

2013
The Physical Society of Japan Tokyo

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Please use a persistent id in citations: doi:10.7566/JPSJS.82SA.SA016

Abstract: The ps to ns dynamics of the protein alcohol dehydrogenase (ADH) has been measured in dilute solution by time-of-flight (TOF) neutron spectroscopy. The investigation extends previous experiments on ADH solutions with neutron-spin-echo spectroscopy. The interpretation of TOF experiments used the diffusion data from NSE as input to decribe the observed slow component of the quasielastic spectra, in addition a fast component to be associated to mobile groups in the protein could be observed. The description within a simple model for translational and rotational diffusion and a fraction of protons with confined local mobility is given together with a novel method to accurately and efficiently account for the instrumental resolution.

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Contributing Institute(s):

1. Neutronenstreuung (ICS-1)
2. Neutronenstreuung (Neutronenstreuung ; JCNS-1)

Research Program(s):

1. 451 - Soft Matter Composites (POF2-451) (POF2-451)
2. 54G - JCNS (POF2-54G24) (POF2-54G24)

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Database coverage:
Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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