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| Hauptseite > Publikationsdatenbank > Neural correlates of reactive aggression in children with attention-deficit/hyperactivity disorder and comorbid disruptive behaviour disorders |
| Hauptseite > Publikationsdatenbank > Neural correlates of reactive aggression in children with attention-deficit/hyperactivity disorder and comorbid disruptive behaviour disorders |
| Journal Article | FZJ-2015-05382 |
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2016
Wiley-Blackwell
Oxford [u. a.]
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Please use a persistent id in citations: doi:10.1111/acps.12475
Abstract: ObjectiveAttention deficit hyperactivity disorder (ADHD) is often linked with impulsive and aggressive behaviour, indexed by high comorbidity rates between ADHD and disruptive behaviour disorders (DBD). The present study aimed to investigate underlying neural activity of reactive aggression in children with ADHD and comorbid DBD using functional neuroimaging techniques (fMRI).MethodEighteen boys with ADHD (age 9–14 years, 10 subjects with comorbid DBD) and 18 healthy controls were administered a modified fMRI-based version of the ‘Point Subtraction Aggression Game’ to elicit reactive aggressive behaviour. Trials consisted of an ‘aggression phase’ (punishment for a fictitious opponent) and an ‘outcome phase’ (presentation of the trial outcome).ResultsDuring the aggression phase, higher aggressive responses of control children were accompanied by higher activation of the ventral anterior cingulate cortex and the temporoparietal junction. Patients displayed inverted results. During the outcome phase, comparison between groups and conditions showed differential activation in the dorsal striatum and bilateral insular when subjects gained points. Losing points was accompanied by differential activation of regions belonging to the insula and the middle temporal sulcus.ConclusionData support the hypothesis that deficient inhibitory control mechanisms are related to increased impulsive aggressive behaviour in young people with ADHD and comorbid DBD.
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