Journal Article

PreJuSER-25196

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dynamic force spectroscopy to probe adhesion strength of living cells

Prechtel, K. ; Bausch, A. R. ; Marchi-Artzner, V. ; Kantlehner, M. ; Kessler, H. ; Merkel, R.FZJ*

2002
APS College Park, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/2172  doi:10.1103/PhysRevLett.89.028101

Abstract: We studied the mechanical strength of the adhesion of living cells to model membranes. The latter contained a RGD lipopeptide which is a high affinity binding site for a cell adhesion molecule (integrin alpha(V)beta(3)). Cells adhered specifically to the vesicles. We used micropipette aspiration for breaking this adhesion with well defined forces. Systematic variation of the rate of force application revealed pronounced kinetic effects. The dependence of the detachment forces on the loading rate was well described by a power law (exponent approximate to0.4), in agreement with recent theoretical work.

Keyword(s): J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Institut für biologisch-anorganische Grenzflächen (ISG-4)

Research Program(s):

1. Kondensierte Materie (M02)

Appears in the scientific report 2002
Notes: This version is available at the following Publisher URL: http://prl.aps.org

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