Neurofunctional topography of the human hippocampus

Robinson, Jennifer L; Hill, Ashley C; Bottenhorn, Katherine L; Barron, Daniel S; Salibi, Nouha; Murphy, Jerry E; Fox, Peter T; Eickhoff, Simon; Kirby, Lauren A J; Katz, Jeffrey S

doi:10.1002/hbm.22987

Typ	Amount	VAT	Currency	Share	Status	Cost centre
Permission	146.15	0.00	EUR	100.00 %	(Zahlung erfolgt)	40400 / E.40401.58
Sum	146.15	0.00	EUR
Total	146.15

Journal Article

FZJ-2015-05661

Neurofunctional topography of the human hippocampus

Robinson, J. L. (Corresponding author) ; Barron, D. S. ; Kirby, L. A. J. ; Bottenhorn, K. L. ; Hill, A. C. ; Murphy, J. E. ; Katz, J. S. ; Salibi, N. ; Eickhoff, S.FZJ* ; Fox, P. T.

2015
Wiley-Liss New York, NY

Human brain mapping 36(12), 5018–5037 (2015) [10.1002/hbm.22987]

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Please use a persistent id in citations: doi:10.1002/hbm.22987

Abstract: Much of what was assumed about the functional topography of the hippocampus was derived from a single case study over half a century ago. Given advances in the imaging sciences, a new era of discovery is underway, with potential to transform the understanding of healthy processing as well as the ability to treat disorders. Coactivation-based parcellation, a meta-analytic approach, and ultra-high field, high-resolution functional and structural neuroimaging to characterize the neurofunctional topography of the hippocampus was employed. Data revealed strong support for an evolutionarily preserved topography along the long-axis. Specifically, the left hippocampus was segmented into three distinct clusters: an emotional processing cluster supported by structural and functional connectivity to the amygdala and parahippocampal gyrus, a cognitive operations cluster, with functional connectivity to the anterior cingulate and inferior frontal gyrus, and a posterior perceptual cluster with distinct structural connectivity patterns to the occipital lobe coupled with functional connectivity to the precuneus and angular gyrus. The right hippocampal segmentation was more ambiguous, with plausible 2- and 5-cluster solutions. Segmentations shared connectivity with brain regions known to support the correlated processes. This represented the first neurofunctional topographic model of the hippocampus using a robust, bias-free, multimodal approach. Hum Brain Mapp, 2015. © 2015 Wiley Periodicals, Inc.

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