Journal Article

FZJ-2015-07499

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png MeshAndCollect : an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines

Zander, U. ; Bourenkov, G. ; Popov, A. N. ; de Sanctis, D. ; Svensson, O. ; McCarthy, A. A. ; Round, E. ; Gordeliy, V.FZJ* ; Mueller-Dieckmann, C. ; Leonard, G. A. (Corresponding author)

2015
Wiley-Blackwell Oxford

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Please use a persistent id in citations: doi:10.1107/S1399004715017927

Abstract: Here, an automated procedure is described to identify the positions of many cryocooled crystals mounted on the same sample holder, to rapidly predict and rank their relative diffraction strengths and to collect partial X-ray diffraction data sets from as many of the crystals as desired. Subsequent hierarchical cluster analysis then allows the best combination of partial data sets, optimizing the quality of the final data set obtained. The results of applying the method developed to various systems and scenarios including the compilation of a complete data set from tiny crystals of the membrane protein bacteriorhodopsin and the collection of data sets for successful structure determination using the single-wavelength anomalous dispersion technique are also presented.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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